R&D

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    No.1

    Trophic molecules derived from human mesenshymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation.

    Islet

    Trophic molecules derived from human mesenshymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation.

    2010

    No.2

    Cartilage oligomeric matrix protein-angiopoientin-1 enhances angiogenesis of isolated islet and maintains normoglycemia following transplantation.

    Islet

    Cartilage oligomeric matrix protein-angiopoientin-1 enhances angiogenesis of isolated islet and maintains normoglycemia following transplantation.

    2010

    No.3

    AFT024 cell line in co-culture system using high pore density insert (HPDI) maintains hematopoietic stem/progenitor cells (HSCs/HPCs) as more primitive state through histone modification.

    MSC

    AFT024 cell line in co-culture system using high pore density insert (HPDI) maintains hematopoietic stem/progenitor cells (HSCs/HPCs) as more primitive state through histone modification.

    2010

    No.4

    Human T cell development in the liver of humanized NOD/SCID/IL-2R(NSG) mice generated by intrahepatic injection of CD34+ human(h) cord blood(CB) cells.

    Hu-mouse

    Human T cell development in the liver of humanized NOD/SCID/IL-2R(NSG) mice generated by intrahepatic injection of CD34+ human(h) cord blood(CB) cells.

    2011

    No.5

    Human B Cell Development and Antibody Production in Humanized NOD/SCID/IL-2Rγnull (NSG) Mice Conditioned by Busulfan.

    Hu-mouse

    Human B Cell Development and Antibody Production in Humanized NOD/SCID/IL-2Rγnull (NSG) Mice Conditioned by Busulfan.

    2011

    No.6

    The effect of human fetal liver-derived mesenchymal stem cells on CD34(+) hematopoietic stem cell repopulation in NOD/Shi-scid/IL-2Rã(null) mice.

    Hu-mouse

    The effect of human fetal liver-derived mesenchymal stem cells on CD34(+) hematopoietic stem cell repopulation in NOD/Shi-scid/IL-2Rã(null) mice.

    2011

    No.7

    Improved quantification of islet transplants by magnetic resonance imaging with resovist.

    Islet

    Improved quantification of islet transplants by magnetic resonance imaging with resovist.

    2011

    No.8

    Co-transplantation of fetal bone tissue facilitates the development and reconstitution in human B cells in humanized NOD/SCID/IL-2Rγnull (NSG) mice.

    Hu-mouse

    Co-transplantation of fetal bone tissue facilitates the development and reconstitution in human B cells in humanized NOD/SCID/IL-2Rγnull (NSG) mice.

    2011

    No.9

    In situ induction of dendritic cell–based T cell tolerance in humanized mice and nonhuman primates

    Hu-mouse

    In situ induction of dendritic cell–based T cell tolerance in humanized mice and nonhuman primates

    2011

    No.10

    Enhancement of the immunosuppressive effect of human adipose tissue-derived mesenchymal stromal cells through HLA-G1 expression.

    MSC

    Enhancement of the immunosuppressive effect of human adipose tissue-derived mesenchymal stromal cells through HLA-G1 expression.

    2012

    No.11

    Systemic human T cell developmental processes in humanized mice cotransplanted with human fetal thymus/liver tissue and hematopoietic stem cells.

    Hu-mouse

    Systemic human T cell developmental processes in humanized mice cotransplanted with human fetal thymus/liver tissue and hematopoietic stem cells.

    2012

    No.12

    A Therapeutic Strategy for Metastatic Malignant Fibrous Histiocytoma Through Mesenchymal Stromal Cell-Mediated TRAIL Production.

    MSC

    A Therapeutic Strategy for Metastatic Malignant Fibrous Histiocytoma Through Mesenchymal Stromal Cell-Mediated TRAIL Production.

    2013

    No.13

    Optimal device and method for transportation of isolated porcine islet

    Islet

    Optimal device and method for transportation of isolated porcine islet

    2013

    No.14

    Establishment of primary xenograft model from newly characterized patient extrauterine carcinosarcoma.

    Sarcoma

    Establishment of primary xenograft model from newly characterized patient extrauterine carcinosarcoma.

    2013

    No.15

    Therapeutic efficacy of human embryonic stem cell-derived endothelial cells in humanized mouse models harboring a human immune system

    Hu-mouse

    Therapeutic efficacy of human embryonic stem cell-derived endothelial cells in humanized mouse models harboring a human immune system

    2013

    No.16

    Generation of humanized liver mouse model by transplanted of patient-derived fresh human hepatocytes

    Hu-mouse

    Generation of humanized liver mouse model by transplanted of patient-derived fresh human hepatocytes

    2014

    No.17

    Gankyrin is a predictive and oncogenic factor in well-differentiated and dedifferentiated liposarcoma

    Sarcoma

    Gankyrin is a predictive and oncogenic factor in well-differentiated and dedifferentiated liposarcoma

    2014

    No.18

    The analysis of mutations and exon deletions at TSC2 gene in angiomyolipomas associated with tuberous sclerosis complex

    Sarcoma

    The analysis of mutations and exon deletions at TSC2 gene in angiomyolipomas associated with tuberous sclerosis complex

    2014

    No.19

    SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma

    Sarcoma

    SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma

    2015

    No.20

    Comparison of Methods for Determining ABO Blood Type in Cynomolgus Macaques (Macaca fascicularis).

    Non-Human Primates

    Comparison of Methods for Determining ABO Blood Type in Cynomolgus Macaques (Macaca fascicularis).

    2015

    No.21

    Effects of Lymphocyte Profile on Development of EBV-induced Lymphoma Subtypes in Humanized Mice

    Hu-mouse

    Effects of Lymphocyte Profile on Development of EBV-induced Lymphoma Subtypes in Humanized Mice

    2015

    No.22

    Transplantation of human spleen into immunodeficient NOD/SCID IL2Rnull mice generates humanized mice that improve functional B cell development

    Hu-mouse

    Transplantation of human spleen into immunodeficient NOD/SCID IL2Rnull mice generates humanized mice that improve functional B cell development

    2015

    No.23

    The Introduction of Human Heme Oxygenase-1 and Soluble Tumor Necrosis Factor-α Receptor Type I With Human IgG1 Fc in Porcine Islets Prolongs Islet Xenograft Survival in Humanized Mice.

    Islet

    The Introduction of Human Heme Oxygenase-1 and Soluble Tumor Necrosis Factor-α Receptor Type I With Human IgG1 Fc in Porcine Islets Prolongs Islet Xenograft Survival in Humanized Mice.

    2016

    No.24

    Comparative efficacies of long-term serial transplantation of syngeneic, allogeneic, xenogeneic, or CTLA4Ig overproducing xenogeneic adipose tissue-derived mesenchymal stem cells on murine systemic lupus erythematosus.

    autoimmune disease

    Comparative efficacies of long-term serial transplantation of syngeneic, allogeneic, xenogeneic, or CTLA4Ig overproducing xenogeneic adipose tissue-derived mesenchymal stem cells on murine systemic lupus erythematosus.

    2016

    No.25

    Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin

    Non-Human Primates

    Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin

    2016

    No.26

    Examination of endothelial cell-induced epidermal regeneration in a mice-based chimney wound model.

    MSC

    Examination of endothelial cell-induced epidermal regeneration in a mice-based chimney wound model.

    2016

    No.27

    Molecular immunology profiles of monkeys following xenografting with the islets and heart of α-1,3-galactosyltransferase knockout pigs.

    Islet

    Molecular immunology profiles of monkeys following xenografting with the islets and heart of α-1,3-galactosyltransferase knockout pigs.

    2016

    No.28

    Mycobacterium tuberculosis infections in cynomolgus monkey transplant recipients and institution of a screening program for the prevention and control of tuberculosis

    Non-Human Primates

    Mycobacterium tuberculosis infections in cynomolgus monkey transplant recipients and institution of a screening program for the prevention and control of tuberculosis

    2016

    No.29

    Comparative characterization of mesenchymal stem cells from multiple abdominal adipose tissues and enrichment of angiogenic ability via CD146 molecule

    MSC

    Comparative characterization of mesenchymal stem cells from multiple abdominal adipose tissues and enrichment of angiogenic ability via CD146 molecule

    2016

    No.30

    Mesenchymal stem cell transplantation can restore lupus disease-associated miRNA expression and Th1/Th2 ratios in a murine model of SLE

    autoimmune disease

    Mesenchymal stem cell transplantation can restore lupus disease-associated miRNA expression and Th1/Th2 ratios in a murine model of SLE

    2016

    No.31

    Morphologic and Doppler Findings from Hepatic Ultrasonography of Normal Cynomolgus Monkeys (Macaca fascicularis).

    Non-Human Primates

    Morphologic and Doppler Findings from Hepatic Ultrasonography of Normal Cynomolgus Monkeys (Macaca fascicularis).

    2017

    No.32

    Simultaneous Subtotal Pancreatectomy and Streptozotocin Injection for Diabetes Modeling in Cynomolgus Monkeys.

    Islet

    Simultaneous Subtotal Pancreatectomy and Streptozotocin Injection for Diabetes Modeling in Cynomolgus Monkeys.

    2017

    No.33

    Xenotransplantation of layer-by-layer encapsulated non-human primate islets with a specified immunosuppressive drug protocol.

    Islet

    Xenotransplantation of layer-by-layer encapsulated non-human primate islets with a specified immunosuppressive drug protocol.

    2017

    No.34

    A Simple Way to Eradicate Methicillin-Resistant Staphylococcus aureus in Cynomolgus Macaques (Macaca fascicularis).

    Non-Human Primates

    A Simple Way to Eradicate Methicillin-Resistant Staphylococcus aureus in Cynomolgus Macaques (Macaca fascicularis).

    2017

    No.35

    Therapeutic strategies for locally recurrent and metastatic de-differentiated liposarcoma with Herpes Simplex Virus-Thymidine Kinase-Expressing Mesenchymal Stromal Cells

    Sarcoma

    Therapeutic strategies for locally recurrent and metastatic de-differentiated liposarcoma with Herpes Simplex Virus-Thymidine Kinase-Expressing Mesenchymal Stromal Cells

    2017

    No.36

    Tumor Suppression Efficacy of Heat Shock Protein 90 Inhibitor 17AAG in a Liposarcoma Mouse Model

    Sarcoma

    Tumor Suppression Efficacy of Heat Shock Protein 90 Inhibitor 17AAG in a Liposarcoma Mouse Model

    2017

    No.37

    Technique for orthotopic liver transplantation in cynomolgus monkeys (Macaca fascicularis)

    Transplatation Immunology

    Technique for orthotopic liver transplantation in cynomolgus monkeys (Macaca fascicularis)

    2018

    No.38

    Therapeutic effects of anti-CD154 antibody in cynomolgus monkeys with advanced rheumatoid arthritis

    autoimmune disease

    Therapeutic effects of anti-CD154 antibody in cynomolgus monkeys with advanced rheumatoid arthritis

    2018

    No.39

    Role of human CD200 overexpression in pig-to-human xenogeneic immune response compared with human CD47 overexpression

    Transplatation Immunology

    Role of human CD200 overexpression in pig-to-human xenogeneic immune response compared with human CD47 overexpression

    2018

    No.40

    Highly Angiogenic, Nonthrombogenic Bone Marrow Mononuclear Cell-Derived Spheroids in Intraportal Islet Transplantation

    Islet

    Highly Angiogenic, Nonthrombogenic Bone Marrow Mononuclear Cell-Derived Spheroids in Intraportal Islet Transplantation

    2018

    No.41

    Three-Dimensional Bioprinting of Hepatic Structures with Directly Converted Hepatocyte-Like Cells.

    Hepatocyte

    Three-Dimensional Bioprinting of Hepatic Structures with Directly Converted Hepatocyte-Like Cells.

    2018

    No.42

    Polymeric nano-shielded islets with heparin-polyethylene glycol in a non-human primate model

    Islet

    Polymeric nano-shielded islets with heparin-polyethylene glycol in a non-human primate model

    2018

    No.43

    Ectopic vascularized bone formation by human umbilical cord-derived mesenchymal stromal cells expressing bone morphogenetic factor-2 and endothelial cells

    MSC

    Ectopic vascularized bone formation by human umbilical cord-derived mesenchymal stromal cells expressing bone morphogenetic factor-2 and endothelial cells

    2018

    No.44

    Effects of Transplanted Islets Nano-Encapsulated with Hyperbranched Polyethylene Glycol and Heparin on Microenvironment Reconstruction and Glucose Control.

    Islet

    Effects of Transplanted Islets Nano-Encapsulated with Hyperbranched Polyethylene Glycol and Heparin on Microenvironment Reconstruction and Glucose Control.

    2018

    No.45

    Establishment of a novel PDX mouse model and evaluation of the tumor suppression efficacy of bortezomib against liposarcoma

    Sarcoma

    Establishment of a novel PDX mouse model and evaluation of the tumor suppression efficacy of bortezomib against liposarcoma

    2019

    No.46

    CKD-506, a novel HDAC6-selective inhibitor, improves renal outcomes and survival in a mouse model of systemic lupus erythematosus.

    autoimmune disease

    CKD-506, a novel HDAC6-selective inhibitor, improves renal outcomes and survival in a mouse model of systemic lupus erythematosus.

    2018

    No.47

    Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells

    Hepatocyte

    Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells

    2019

    No.48

    Reduced variability in pharmacokinetics of tacrolimus following intramuscular injection compared to oral administration in Cynomolgus monkeys: investigating optimal dosing regimens

    Non-Human Primates

    Reduced variability in pharmacokinetics of tacrolimus following intramuscular injection compared to oral administration in Cynomolgus monkeys: investigating optimal dosing regimens

    2019

    No.49

    Reconstituting human cutaneous regeneration in humanized mice under endothelial cell therapy

    Hu-mouse

    Reconstituting human cutaneous regeneration in humanized mice under endothelial cell therapy

    2019

    No.50

    Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

    Sarcoma

    Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

    2019

    No.51

    Relationships between Cytokine Levels and Disease Parameters during the Development of a Collagen-induced Arthritis Model in Cynomolgus Macaques (Macaca fascicularis).

    autoimmune disease

    Relationships between Cytokine Levels and Disease Parameters during the Development of a Collagen-induced Arthritis Model in Cynomolgus Macaques (Macaca fascicularis).

    2019

    No.52

    Multi-layer surface modification of pancreatic islets for magnetic resonance imaging using ferumoxytol.

    Islet

    Multi-layer surface modification of pancreatic islets for magnetic resonance imaging using ferumoxytol.

    2019

    No.53

    Comparative study of human and cynomolgus T-cell depletion with rabbit anti-thymocyte globulin (rATG) treatment-for dose adjustment in a non-human primate kidney transplantation model

    Kidney Transplant

    Comparative study of human and cynomolgus T-cell depletion with rabbit anti-thymocyte globulin (rATG) treatment-for dose adjustment in a non-human primate kidney transplantation model

    2019

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